{"product_id":"kpv-10mg-peptide","title":"KPV","description":"\u003ch2\u003eKPV (10mg Vials)\u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCost per milligram\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e$3.20 – $4.40\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e99.90%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eCertified Endotoxin-safe\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eYes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIndependently Tested\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eYes\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eManufacturer ID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eVI32\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBatch ID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eKV202601\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003eResearch Studies\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003e(For educational purposes only)\u003c\/em\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eStudy 1: PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors:\u003c\/strong\u003e Guillaume Dalmasso, Laetitia Charrier-Hisamuddin, Hang Thi Thu Nguyen, Yutao Yan, Shanthi Sitaraman, Didier Merlin\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e\u003cbr\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2431115\/\u003c\/p\u003e\n\u003ch4\u003eScientific Findings\u003c\/h4\u003e\n\u003cp\u003eThis study investigated the anti-inflammatory activity of the tripeptide KPV in human intestinal epithelial cells and immune cells. Researchers demonstrated that KPV is transported into cells through the human peptide transporter PepT1, allowing intracellular activity at nanomolar concentrations.\u003c\/p\u003e\n\u003cp\u003eLaboratory testing showed that KPV significantly inhibited activation of the NF-κB and MAP kinase signaling pathways, two major regulators of inflammatory responses. The peptide also reduced secretion of multiple pro-inflammatory cytokines and demonstrated measurable activity in both intestinal epithelial and immune cell models.\u003c\/p\u003e\n\u003cp\u003eThese findings suggest that KPV exerts anti-inflammatory effects through cellular uptake via PepT1 followed by modulation of intracellular inflammatory signaling cascades.\u003c\/p\u003e\n\u003ch4\u003ePlain English Interpretation\u003c\/h4\u003e\n\u003cp\u003eScientists studied how KPV works in intestinal and immune cells grown in laboratory conditions. They found that KPV can enter cells through a specialized transporter called PepT1, which normally helps absorb small peptides.\u003c\/p\u003e\n\u003cp\u003eOnce inside the cells, KPV reduced activity of several important inflammatory pathways and lowered production of inflammatory signaling molecules. The study suggests that KPV may support research into cellular inflammatory processes by helping regulate how cells respond to inflammatory stimuli.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eStudy 2: Lysine-Proline-Valine Peptide Mitigates Fine Dust-Induced Keratinocyte Apoptosis and Inflammation\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors:\u003c\/strong\u003e Junghee Sung, Seo-Young Ju, SeungHyun Park, Won-Kyo Jung, Jae-Young Je, Sei-Jung Lee\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e\u003cbr\u003ehttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S004081662500117X\u003c\/p\u003e\n\u003ch4\u003eScientific Findings\u003c\/h4\u003e\n\u003cp\u003eThis investigation evaluated KPV in human keratinocyte cultures exposed to particulate matter (PM10). Exposure to PM10 increased oxidative stress, inflammatory signaling, and cell death markers.\u003c\/p\u003e\n\u003cp\u003eTreatment with KPV significantly improved cell viability while reducing reactive oxygen species (ROS) production and inflammatory mediator release. KPV also suppressed activation of ERK, p38 MAPK, and NF-κB pathways, which are commonly associated with oxidative stress responses.\u003c\/p\u003e\n\u003cp\u003eIn both conventional cell cultures and three-dimensional skin models, KPV demonstrated protective effects against pollution-induced cellular damage and inflammatory responses.\u003c\/p\u003e\n\u003ch4\u003ePlain English Interpretation\u003c\/h4\u003e\n\u003cp\u003eResearchers examined whether KPV could help protect skin cells from damage caused by air pollution particles. The study found that KPV reduced harmful oxidative stress signals and helped maintain healthier cell function when skin cells were exposed to fine dust particles.\u003c\/p\u003e\n\u003cp\u003eBy lowering inflammatory activity and reducing stress-related cellular damage, KPV showed promising properties for research involving skin barrier function, oxidative stress, and cellular resilience under challenging environmental conditions.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eStudy 3: Inhibition of Cellular and Systemic Inflammation Cues in Human Bronchial Epithelial Cells by Melanocortin-Related Peptides\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Stephen C. Land\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSource:\u003c\/strong\u003e\u003cbr\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3403564\/\u003c\/p\u003e\n\u003ch4\u003eScientific Findings\u003c\/h4\u003e\n\u003cp\u003eThis study explored the molecular mechanism underlying KPV's anti-inflammatory activity in human bronchial epithelial cells. Researchers found that KPV dose-dependently reduced NF-κB transcriptional activity, matrix metalloproteinase-9 (MMP-9) activity, and secretion of inflammatory chemokines including IL-8 and eotaxin.\u003c\/p\u003e\n\u003cp\u003eMechanistic experiments demonstrated that KPV enters cells and localizes to the nucleus, where it interferes with the transport of the NF-κB p65RelA subunit. Specifically, KPV competitively inhibited interaction between p65RelA and importin-α3, preventing activation of downstream inflammatory gene expression.\u003c\/p\u003e\n\u003cp\u003eThese findings identify a direct intracellular mechanism through which KPV can regulate inflammatory signaling pathways.\u003c\/p\u003e\n\u003ch4\u003ePlain English Interpretation\u003c\/h4\u003e\n\u003cp\u003eScientists wanted to understand exactly how KPV reduces inflammation inside cells. They discovered that KPV can move into cells and block a key inflammatory protein from reaching the cell nucleus, where inflammatory genes are normally activated.\u003c\/p\u003e\n\u003cp\u003eBy interrupting this process, KPV helped reduce production of several inflammatory signals. This research provides insight into how KPV may influence cellular inflammatory responses through highly targeted intracellular mechanisms.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003eResearch Use Statement\u003c\/h3\u003e\n\u003cp\u003eKPV is a synthetic tripeptide composed of lysine, proline, and valine residues. Current research has investigated its interactions with inflammatory signaling pathways, oxidative stress responses, epithelial barrier systems, and cellular transport mechanisms.\u003c\/p\u003e\n\u003cp\u003eAll products are intended for \u003cstrong\u003ein-vitro laboratory research purposes only\u003c\/strong\u003e. Not for human use, veterinary use, therapeutic application, or diagnostic procedures.\u003c\/p\u003e","brand":"My Store 3","offers":[{"title":"Default Title","offer_id":47911685161178,"sku":null,"price":35.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/4615\/5994\/files\/JPMolecularLabsKPVpeptidevialwithresearchlabel.png?v=1779600957","url":"https:\/\/zzpeptide.com\/products\/kpv-10mg-peptide","provider":"JP MOLECULAR LABS","version":"1.0","type":"link"}