MOTS-c

MOTS-c (10mg Vials)

MOTS-c is a mitochondrial-derived peptide (MDP) widely studied for its potential role in cellular metabolism, mitochondrial signaling, skeletal muscle function, and metabolic regulation. As one of the most extensively researched mitochondrial peptides, MOTS-c has attracted significant scientific interest for its involvement in energy homeostasis, exercise adaptation, and cellular stress response pathways.

Each batch undergoes rigorous third-party analytical testing for purity, endotoxin levels, sterility, and heavy metals to ensure consistent quality for laboratory research applications.

Why Researchers Study MOTS-c

MOTS-c is encoded within mitochondrial DNA and functions as a signaling peptide involved in cellular adaptation to metabolic stress. Research has explored its effects on mitochondrial communication, skeletal muscle physiology, energy metabolism, inflammatory signaling pathways, and cellular resilience under challenging metabolic conditions.

Recent studies suggest that MOTS-c may influence multiple intracellular pathways associated with metabolic regulation and mitochondrial function, making it a growing area of interest within peptide and longevity research.

Research Studies

For educational purposes only.

Study 1: MOTS-c Promotes Muscle Differentiation In Vitro

Authors: Sandra García-Benlloch, Francisco Revert-Ros, Jose Rafael Blesa, Rafael Alis

Source:
https://www.sciencedirect.com/science/article/pii/S0196978122001061

Scientific Findings

Researchers investigated the effects of MOTS-c on human and murine muscle precursor cells. The study demonstrated that wild-type MOTS-c significantly enhanced myotube formation and muscle cell differentiation. Mechanistic analysis suggested that MOTS-c modulates STAT3 transcriptional activity through a specific SH2-binding region, helping maintain myogenin expression during muscle development.

A modified peptide lacking a key tyrosine residue failed to produce similar effects, highlighting the importance of this region for biological activity.

Plain English Interpretation

Scientists found that MOTS-c helps immature muscle cells develop into mature muscle fibers. The peptide appeared to support the normal muscle-building process and helped counteract cellular signals that can interfere with muscle development.

These findings contribute to growing scientific interest in MOTS-c's potential role in muscle physiology and exercise-related research.

Study 2: MOTS-c Interacts with Bcl-2 to Support Mitochondrial Function

Authors: Huanyu Lu, Linni Fan, Wenli Zhang, Guo Chen, An Xiang, Li Wang, Zifan Lu, Yue Zhai

Source:
https://www.sciencedirect.com/science/article/pii/S2211124723015991

Scientific Findings

This study identified a direct interaction between MOTS-c and the anti-apoptotic protein Bcl-2. Researchers found that MOTS-c increased Bcl-2 stability by reducing protein degradation through ubiquitination pathways.

Experimental models demonstrated that this interaction was associated with improvements in mitochondrial function, cellular metabolism, inflammatory signaling, and tissue integrity under metabolically stressful conditions.

Plain English Interpretation

Researchers discovered that MOTS-c helps support important cellular protection systems by interacting with proteins involved in cell survival. This interaction helped maintain healthier mitochondrial activity and reduced signs of metabolic stress in laboratory models.

The findings provide additional evidence that MOTS-c may play an important role in mitochondrial biology and cellular energy regulation.

Study 3: MOTS-c Modulates Skeletal Muscle Function Through CK2 Activation

Authors: Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, et al.

Source:
https://www.cell.com/iscience/fulltext/S2589-0042(24)02437-4

Scientific Findings

Researchers identified protein kinase CK2 as a direct molecular target of MOTS-c. Laboratory experiments demonstrated that MOTS-c physically binds to CK2 and enhances its enzymatic activity.

Further analysis revealed that naturally occurring MOTS-c variants with reduced CK2 binding capacity also displayed diminished biological activity, supporting the functional importance of this interaction.

Plain English Interpretation

Scientists discovered that MOTS-c works by activating an important cellular enzyme called CK2. This interaction appears to influence multiple metabolic and muscle-related processes inside cells.

The findings help explain how MOTS-c produces many of its observed biological effects and provide valuable insight into the molecular mechanisms underlying mitochondrial peptide signaling.

MOTS-c Research Applications

• Mitochondrial signaling research
• Cellular metabolism studies
• Exercise physiology investigations
• Skeletal muscle research
• Healthy aging research models
• Metabolic adaptation studies
• Mitochondrial stress response investigations
• Cellular energy regulation research

Research Use Statement

MOTS-c is supplied exclusively for laboratory and scientific research purposes. This product is intended for in-vitro research use only.

Not for human consumption, therapeutic use, veterinary use, diagnostic procedures, or clinical applications.

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